• Marios Georgiou, Elizabeth Papathanassoglou, and Theodoros Xanthos.
• Nursing, American Medical Center, Nicosia, Cyprus; Cyprus Resuscitation Council, Nicosia, Cyprus.
• Resuscitation. 2014 Nov 1; 85 (11): 1586-93.

BackgroundHigh quality chest compressions is the most significant factor related to improved short-term and long-term outcome in cardiac arrest. However, considerable controversy exists over the mechanisms involved in driving blood flow.ObjectivesThe aim of this systematic review is to elucidate major mechanisms involved in effective compression-mediated blood flow during adult cardiopulmonary resuscitation (CPR).Design And SettingSystematic review of studies identified from the bibliographic databases of PubMed/Medline, Cochrane, and Scopus.Selection CriteriaAll human and animal studies including information on the responsible mechanisms of compression-related blood flow.Data Collection And AnalysisTwo reviewers (MG, TX) independently screened all potentially relevant titles and abstracts for eligibility, by using a standardized data-worksheet.Main ResultsForty seven studies met the inclusion criteria. Because of the heterogeneity in outcome measures, quantitative synthesis of evidence was not feasible. Evidence was critically synthesized in order to answer the review questions, taking into account study heterogeneity and validity. The number of included studies per category is as follows: blood flow during chest compression, nine studies; blood flow during chest decompression, six studies; effect of chest compression on cerebral blood flow, eight studies; active compression-decompression CPR, 14 studies; and effect of ventilation on compression-related blood flow, 13 studies.ConclusionThe evidence so far is inconclusive regarding the major responsible mechanism in compression-related blood flow. Although both 'cardiac pump' and 'thoracic pump' have a key role, the effect of each mechanism is highly depended on other resuscitation parameters, such as positive pressure ventilation and compression depth.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

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