• Francesco Saverio Bersani, Ornella Corazza, Gabriella Albano, Giuseppe Valeriani, Rita Santacroce, Flaminia Bolzan Mariotti Posocco, Eduardo Cinosi, Pierluigi Simonato, Giovanni Martinotti, Giuseppe Bersani, and Fabrizio Schifano.
• Department of Neurology and Psychiatry, Sapienza University of Rome, 00185 Rome, Italy ; Department of Postgraduate Medicine, School of Life and Medical Sciences, University of Hertfordshire, AL10 9AB Hatfield, UK.
• Biomed Res Int. 2014 Jan 1;2014:734749.

IntroductionThe use of novel psychoactive substances (NPSs) has rapidly increased as well as their online availability. The aim of this paper is to provide a comprehensive review of the nature and the risks associated with 25C-NBOMe, which has recently appeared in the drug market.MethodsA systematic analysis of the scientific literature and a qualitative assessment of online and media resources (e.g., e-newsgroups, chat-rooms, and e-newsletters) in 10 languages were carried out.Results25C-NBOMe is sold online as legal LSD or as research chemical with different designations such as "Boom," "Pandora," "Holland film," or "N-bomb." It is a partial agonist of 5-HT2A receptors. It is usually ingested orally/sublingually and, less commonly, nasally, through injection, vaginally, rectally, and smoked. Its effects include sublingual numbing, stimulation, "body high," hallucinations, dissociation, and anxiety. 25C-NBOMe presents high risk of overdoses; acute toxicity and fatalities have been reported.Conclusions25C-NBOMe consumption represents an emerging phenomenon with potential harmful effects. Its use is increased by its online availability at low costs. Health and other professionals should be informed about this new trend of substance use.

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