• Rinsho Ketsueki · Feb 2011

    Case Reports

    [Successful treatment with the combination of recombinant human soluble thrombomodulin and gabexate mesilate in three patients with obstetric disseminated intravascular coagulation].

    • Takeo Kumura, Yasutaka Aoyama, Hiroyoshi Ichihara, Shirou Koh, Atuko Mugitani, Hitomi Hayakawa, Keisuke Yukioka, Dan Kinoshita, Masako Nakagawa, and Noriyuki Yamazaki.
    • Depatment of Hematology, Seichokai Fuchu Hospital.
    • Rinsho Ketsueki. 2011 Feb 1;52(2):68-72.

    AbstractRecombinant human soluble thrombomodulin (rTM) is a new drug for the treatment of disseminated intravascular coagulation (DIC), although the effects on obstetric DIC have not yet been fully elucidated. We report herein three patients with obstetric DIC caused by placental abruption, hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, and atonic bleeding, respectively. In all three cases, treatment with rTM proved successful, suggesting that rTM is an efficient method for treating obstetric DIC.

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