• Song Luo, Lijuan Yang, and Lijin Wang.
• Department of Neurology, the First Hospital of Bengbu Medical College, Bengbu 233004, China. Electronic address: 542462407@qq.com.
• J Neuroradiology. 2015 Oct 1; 42 (5): 255-60.

Background And PurposeTo investigate detection of ischemic penumbra in stroke patients with acute cerebral infarction by susceptibility-weighted imaging (SWI) in comparison with perfusion-weighted imaging (PWI).Materials And MethodsThis study included 18 stroke patients with acute infarction who underwent diffusion-weighted imaging (DWI), SWI, PWI, and magnetic resonance angiography (MRA) within 3 days after symptom onset. The Alberta Stroke Program Early CT Score (ASPECTS) was used to evaluate lesions on DWI, SWI, and PWI. DWI-SWI and DWI-PWI mismatches were calculated.ResultsThe DWI-SWI mismatch was not significantly different from the DWI-mean transit time (MTT) mismatch (P=0.163) in evaluating ischemic penumbra. The susceptibility vessel sign (SVS) in SWI occurred in 11 (61%) of 18 patients with cerebral infarction. Stenosis or occlusion of the affected vessels was identified by MRA in 10 (91%) of the 11 SVS-positive patients. The SVS on SWI was significantly associated with the occurrence of damaged vessels or the presence of thrombus in the affected vessels (P=0.047).ConclusionsDWI-SWI mismatch is a good marker for evaluating ischemic penumbra in stroke patients with cerebral infarction. SWI can detect thrombus in the affected vessels, and may be useful for guiding intra-arterial thrombolytic therapy.Copyright © 2014 Elsevier Masson SAS. All rights reserved.

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