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Se Asian J Trop Med · Jan 2009
Anti-tuberculosis drug resistance and HIV co-infection in Phnom Penh, Cambodia.
- Borann Sar, Chantary Keo, Chanthy Leng, Manil Saman, Doung Chan Min, Sarin Chan, Didier Monchy, and Jean-Louis Sarthou.
- Laboratory for Mycobacteriology, Unit of Clinical Testing, Institut Pasteur du Cambodge, Phnom Penh, Kingdom of Cambodia. sborann@pasteur-kh.org
- Se Asian J Trop Med. 2009 Jan 1;40(1):104-7.
AbstractThe objective of this study was to observe the prevalence of drug resistance in Mycobacterium tuberculosis isolates in HIV associated tuberculosis co-infected patients in Phnom Penh City. The isolates of M. tuberculosis were collected during active laboratory-based surveillance. Of the 98 isolates studied, M. tuberculosis resistance to isoniazid was seen in 23.5%, resistance to rifampicin was seen in 16.3% and multidrug-resistance (MDR-TB) was seen in 5.1%. Our findings reveal an alarmingly high level of resistance to isoniazid and rifampicin, and confirms the need for drug susceptibility testing to guide treatment in patients with culture positive tuberculosis.
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