• Martina de Zwaan, Janna Enderle, Sebastian Wagner, Barbara Mühlhans, Beate Ditzen, Olaf Gefeller, James E Mitchell, and Astrid Müller.
• Department of Psychosomatic Medicine and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany. martina.dezwaan@uk-erlangen.de
• J Affect Disord. 2011 Sep 1;133(1-2):61-8.

BackgroundCandidates for bariatric surgery frequently have co-morbid psychiatric problems.MethodsThis study investigated the course and the prognostic significance of preoperative and postoperative anxiety and depressive disorders in 107 extremely obese bariatric surgery patients in a prospective design with face-to-face interviews (SCID) conducted prior to the surgery and postoperatively after 6-12 months and 24-36 months.ResultsThe point prevalence of depressive disorders but not of anxiety disorders decreased significantly after surgery. Preoperative depressive disorders predicted depressive disorders 24-36 months but not 6-12 months after surgery, whereas preoperative anxiety significantly predicted postoperative anxiety disorders at both follow-up time points. Preoperative lifetime and current depressive disorders were unrelated to postoperative weight loss whereas preoperative lifetime, but not current anxiety disorders were of negative prognostic value for postoperative weight loss. Patients with both depressive and anxiety disorders at baseline (current and lifetime) lost significantly less weight after surgery. Postoperative anxiety disorder was not associated with the degree of weight loss at any follow-up time-point; however postoperative depressive disorder was negatively associated with weight loss at the 24-36 month follow-up assessment point.LimitationsMissing data, limited statistical power, self-reported height and weight are the limitations of this study.ConclusionsAs opposed to anxiety disorders, the point prevalence of depressive disorders decreased significantly after bariatric surgery. However, the presence of depressive disorders after bariatric surgery significantly predicted attenuated post-surgical improvements and may signal a need for clinical attention.Copyright © 2011 Elsevier B.V. All rights reserved.

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