• Anaesthesia · Nov 2004

    Randomized Controlled Trial Comparative Study Clinical Trial

    Effect of non-selective, non-steroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors on the PFA-100 closure time.

    • A M Blaicher, H T Landsteiner, J Zwerina, U Leitgeb, I Volf, and K Hoerauf.
    • Department of Anaesthesiology and General Intensive Care, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. a88@am23.com
    • Anaesthesia. 2004 Nov 1;59(11):1100-3.

    AbstractThe place of cyclo-oxygenase (COX)-2 selective non-steroidal anti-inflammatory drugs (NSAIDs) in the peri-operative period remains under discussion. Due to the absence of COX-2 in platelets, the risk of bleeding in patients who use selective NSAIDs is thought to be decreased. We studied the influence of aspirin, diclofenac, lornoxicam and rofecoxib on the in vitro bleeding time using the platelet function analyser (PFA-100). The PFA-100 simulates the process of platelet adhesion and aggregation after vascular injury in vitro. Measurements in 43 volunteers were performed at three time points: before, 3 h, and 12 h after oral ingestion of one of the randomly assigned study medications. Aspirin, diclofenac and lornoxicam had a significant effect on the in vitro closure time, while rofecoxib did not show this effect. This supports the use of COX-2 selective drugs in the peri-operative period to minimise the risk of bleeding.

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