• Franco Cauda, Katiuscia Sacco, Federico D'Agata, Sergio Duca, Dario Cocito, Giuliano Geminiani, Filippo Migliorati, and Gianluca Isoardo.
• CCS fMRI, Koelliker Hospital, Corso Galileo Ferraris, Turin, Italy. franco.cauda@unito.it
• Bmc Neurosci. 2009 Jan 1;10:138.

BackgroundIn this paper we explored thalamocortical functional connectivity in a group of eight patients suffering from peripheral neuropathic pain (diabetic pain), and compared it with that of a group of healthy subjects. We hypothesized that functional interconnections between the thalamus and cortex can be altered after years of ongoing chronic neuropathic pain.ResultsFunctional connectivity was studied through a resting state functional magnetic resonance imaging (fMRI) paradigm: temporal correlations between predefined regions of interest (primary somatosensory cortex, ventral posterior lateral thalamic nucleus, medial dorsal thalamic nucleus) and the rest of the brain were systematically investigated. The patient group showed decreased resting state functional connectivity between the thalamus and the cortex.ConclusionThis supports the idea that chronic pain can alter thalamocortical connections causing a disruption of thalamic feedback, and the view of chronic pain as a thalamocortical dysrhythmia.

24 keywords...

hide…