• Kyoung-Woon Joung, Jun-Young Jo, Wook-Jong Kim, Dae-Kee Choi, Ji-Hyun Chin, Eun-Ho Lee, and In-Cheol Choi.
• Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
• J. Cardiothorac. Vasc. Anesth. 2014 Dec 1; 28 (6): 1440-7.

ObjectiveRecent studies suggested that elevated serum uric acid levels may be associated with the risk of acute kidney injury (AKI) in several settings. However, the effect of uric acid on the risk of AKI after cardiovascular surgery remains uncertain.DesignA retrospective analysis.SettingA tertiary care university hospital.ParticipantsAll consecutive adult patients (n = 1,019) who underwent cardiovascular surgery between January 2011 and May 2012.InterventionsNone.Measurements And Main ResultsPreoperative and perioperative data were assessed in the study population. AKI was defined and staged as serum creatinine concentration-based Acute Kidney Injury Network criteria. Univariate and multivariate logistic regression analyses were conducted to evaluate the association between preoperative uric acid and postoperative AKI. Preoperative elevated uric acid (≥ 6.5 mg/dL) was associated independently with AKI after cardiovascular surgery (odds ratio 1.46; 95% confidence interval 1.04-2.06, p = 0.030). Results were the same in subgroup analyses. Preoperative elevated uric acid (≥ 6.5 mg/dL) also was associated with a higher incidence of prolonged ICU and hospital stay.ConclusionsPreoperative elevated serum uric acid is an independent risk factor for AKI in patients undergoing cardiovascular surgery. This finding suggests that preoperative measurements of serum uric acid concentration may help stratify risks for AKI in these patients.Copyright © 2014 Elsevier Inc. All rights reserved.

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