• Neurology · Feb 1998

    Comparative Study Clinical Trial Controlled Clinical Trial

    Controlled trial of ketorolac in tension-type headache.

    • R N Harden, D Rogers, K Fink, and R H Gracely.
    • Rehabilitation Institute of Chicago, IL 60611, USA.
    • Neurology. 1998 Feb 1;50(2):507-9.

    AbstractIntramuscular ketorolac 60 mg, meperidine 50 mg plus promethazine 25 mg, and normal saline were compared in acute exacerbations of tension-type headache. Forty-one subjects (30 females and 11 males) were randomized into three groups and evaluated by the McGill Short-Form Pain Questionnaire before treatment, and 0.5, 1, 2, 3, 4, 5, and 6 hours after treatment. All three groups showed a significant treatment effect that persisted for the 6 hours of evaluation. Ketorolac treatment was significantly better than placebo at 0.5 and 1 hour by the Visual Analog Scale (VAS) and Pain Rating Index, and better than meperidine at 2 hours (by the VAS). Meperidine and placebo did not differ at any time point. Ketorolac is effective in short-term treatment of tension-type headache.

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