• Yuyuan Li, Yang Sun, Jian Li, Zhe Wang, Yongzhong Lin, Ling Tang, Dandan Xia, Tiezheng Zheng, Xiaohan Yang, Li Sha, and C K Sun.
• Liaoning Provincial Key Laboratory of Cerebral Diseases, Institute for Brain Disorders, Dalian Medical University, Western 9 Lvshunnan Road, Lvshun District, Dalian 116044, PR China. Electronic address: liyuyuan831221@163.com.
• J. Neurol. Sci. 2015 Oct 15; 357 (1-2): 215-21.

ObjectivesUbiquitin carboxy-terminal hydrolase-L1 (UCH-L1) has been established as a potential biomarker of neuronal damage. There is not much information about the effects of white matter lesions (WMLs) on serum and urine UCH-L1 levels in white matter disease patients. This study was aimed to assess whether serum or urine UCH-L1 levels are a reliable marker of brain damage in patients with WMLs.Design And MethodsSerum and urine levels of UCH-L1 were assessed in 125 patients with dizziness, hypertension, type 2 diabetes mellitus, or dyslipidemia. Of these 125 patient cases, 41 showed periventricular WMLs (P-WMLs), 46 showed subcortical WMLs (S-WMLs), and 38 displayed no well-defined WMLs (controls).ResultsSerum UCH-L1 levels were significantly different between the WML group and controls (p<0.05). Further subgroup analysis proved that serum UCH-L1 levels in participants with S-WMLs were significantly increased when compared with controls (p<0.001), but there was no significant differences between controls and patients with P-WMLs (p>0.05). However, urine levels of UCH-L1 were similar between these three groups (p>0.05). In addition, multivariate analysis showed that increased serum UCH-L1 levels were independently associated with the severity of WMLs using Fazekas scale (β=0.432, p<0.001).ConclusionsThese findings suggest that serum UCH-L1 levels may serve as a novel biomarker for neuronal damage from WMLs, especially S-WMLs.Copyright © 2015 Elsevier B.V. All rights reserved.

25 keywords...

hide…