• Tayfun Adanir, Murat Aksun, Uğur Ozgürbüz, Fahri Altin, and Atilla Sencan.
• Department of Anesthesiology, Ataturk Training and Research Hospital, Izmir, Turkey. tadanir@tnn.net
• J Laparoendosc Adv Surg Tech A. 2008 Feb 1;18(1):1-4.

BackgroundIt has been suggested that relative hypovolemia due to overnight fasting may result in postoperative nausea and vomiting (PONV). The aim of this study was to investigate the effect of preoperative and intraoperative hydration (the necessary amount of fluid preoperatively to cover the fluid deficit) on PONV.Materials And MethodsTwo hundred and ten consecutive patients who underwent elective laparoscopic cholecystectomy with The American Society of Anesthesiologists (ASA)-I physical statuses were studied prospectively. The patients were randomly assigned to one of two groups, each having 104 patients. Group 1 received intraoperative volume replacement, but Group-II received preoperative volume replacement. Postoperative antiemetic efficacy was assessed by the ratio of the patients that require an antiemetic over the whole group.ResultsThe PONV was significantly less detected in the preoperative replacement group (48% in Group 2) than the intraoperative one (64% in Group 1) (P = 0.019).ConclusionsPONV was reduced when the fluid deficit was replaced preoperatively.

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