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J Bone Joint Surg Am · Jul 2012
On the prevention and analysis of missing data in randomized clinical trials: the state of the art.
- Daniel O Scharfstein, Joseph Hogan, and Amir Herman.
- Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA. dscharf@jhsph.edu
- J Bone Joint Surg Am. 2012 Jul 18;94 Suppl 1:80-4.
AbstractWe summarize and elaborate on the recently published National Research Council report entitled "The Prevention and Treatment of Missing Data in Clinical Trials." We tailor our discussion to orthopaedic trials. In particular, we discuss the intent-to-treat principle, review study design and prevention ideas to minimize missing data, and present state-of-the-art sensitivity analysis methods for analyzing and reporting the results of studies with missing data.
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