• Neuron · Dec 2006

    Comment

    Painful channels.

    • William A Catterall and Frank H Yu.
    • Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA.
    • Neuron. 2006 Dec 7;52(5):743-4.

    AbstractParoxysmal extreme pain disorder (PEPD), previously known as familial rectal pain (FRP, OMIM 167400), is an inherited disease causing intense burning rectal, ocular, and submandibular pain and flushing. Fertleman et al. (this issue of Neuron) show that mutations in SCN9A, the gene encoding the sodium channel Na(V)1.7 channels, are responsible for this syndrome. Together with earlier work implicating a distinct class of functional mutations in SCN9A in a distinct inherited pain syndrome, these results point to Na(V)1.7 channels as key players in signaling nociceptive information and as a potential target for drug therapy of chronic pain.

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