• Alfonso Galván-Montaño, Gerardo Reyes-García, María de Lourdes Suárez-Roa, and Juan Asbun-Bojalil.
• Subdirección de Pediatría, Hospital General "Dr. Manuel Gea González," Secretaría de Salud, México, D. F., Mexico. gamagq3@hotmail.com
• Cir Cir. 2010 Sep 1;78(5):400-9.

Backgroundanalgesics in pediatric ambulatory surgery must be safe and effective. Acetominophen is safe with moderate efficacy; therefore, we searched for other drugs. In preclinical trials, improved efficacy was reported with the combination of acetaminophen + B vitamins. The aim of this study was to determine the analgesic efficacy of acetaminophen + B vitamins in pediatric ambulatory surgery.Methodswe conducted a clinical, comparative, randomized, double-blind study. We included 56 patients who were divided into four groups of 14 patients for each surgery (circumcision, tonsillectomy, inguinal hernioraphy, orchiopexy). Half of the patients received acetaminophen + B vitamins, and the remaining patients received acetaminophen alone. Variables were drugs, visual analogue scale and time of discharge. χ(2), Student t-test and analysis of variance (ANOVA) were used for statistical analysis.Resultsin children who received acetaminophen + B vitamins during the immediate postoperative period, 58% had a pain score <2 and 89% were discharged with a pain score %lt;1. Both schedules were effective and safe but acetaminophen + B vitamins showed a better pain score.Conclusionsthe adjuvant effect of B vitamins was demonstrated with a better pain score in the immediate postoperative period and at the time of discharge.

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