• Phytomedicine · Jul 2001

    Evaluation of anti-tussive activity of Bergenia ciliata Sternb. rhizome extract in mice.

    • S Sinha, T Murugesan, M Pal, and B P Saha.
    • Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
    • Phytomedicine. 2001 Jul 1;8(4):298-301.

    AbstractThe methanol extract of the rhizome of Bergenia ciliata Sternb. (Saxifragaceae) has been evaluated for its potential in a cough model induced by sulphur dioxide gas in mice. The extract exhibited significant anti-tussive activity in a dose-dependent manner, as compared with control. The antitussive activity of the extract was comparable to that of codeine phosphate (10 mg/kg body wt.), a standard anti-tussive agent. The extract at doses of 100, 200 and 300 mg/kg body wt. (p.o.) showed significant inhibition of cough reflex by 28.7, 33.9 and 44.2%, respectively, within 90 min of the experiment.

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