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J. Cardiothorac. Vasc. Anesth. · Dec 2014
Comparative StudyInteroperator and Intraoperator Variability of Whole Blood Coagulation Assays: A Comparison of Thromboelastography and Rotational Thromboelastometry.
- Lynne Anderson, Isma Quasim, Mark Steven, Stephen F Moise, Ben Shelley, Stefan Schraag, and Andrew Sinclair.
- Department of Anesthesia, Golden Jubilee National Hospital, Clydebank, Scotland. Electronic address: Lynne.Anderson@gjnh.scot.nhs.uk.
- J. Cardiothorac. Vasc. Anesth.. 2014 Dec 1;28(6):1550-7.
ObjectivesNear-patient viscoelastic tests have proved useful in decreasing blood and blood product use in cardiac surgery. Two different analyzers are available, TEG and ROTEM. Many different individuals operate these devices, which raises concern that this factor may significantly affect results. The present study sought to objectively assess variability in results between operators.DesignProspective study.SettingRegional cardiac center.ParticipantsAdult patients undergoing elective cardiac surgery.InterventionsThirty-six mL of blood were taken from each of 21 patients. TEG kaolin and functional fibrinogen (FF) analyses and the equivalent ROTEM INTEM S and FIBTEM S analyses were performed. Six operators performed one of each test per patient to assess interoperator variability. One further operator performed 6 of each test per patient to assess intraoperator variability.Measurements And Main ResultsAll routine measurement parameters were noted and the coefficient of variation (CV) calculated, analyzing comparable parameters. All inter-operator CVs were significantly lower for ROTEM analyses compared with TEG. CV for INTEM S CT/ kaolin r time was 4.7 versus 16.3 and MCF/MA was 2.6 versus 4.3 (p < 0.01). Similarly, FIBTEM S MCF/ FF MA was 8.3 versus 12.2. All intraoperator CVs were significantly lower for ROTEM analyses compared with TEG (p<0.01). CV for INTEM S CT/kaolin r time was 3.1 versus 9.8 and MCF/ MA was 1.6 versus 4. Similarly, FIBTEM S MCF/ MA was 6.9 versus 12.1.ConclusionsThis series of results suggested ROTEM analyses are more reproducible than TEG and, consequently, that ROTEM may be better suited for use in a multiuser environment.Copyright © 2014 Elsevier Inc. All rights reserved.
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