• Acta neurochirurgica · Feb 2010

    Case Reports

    Cystic craniopharyngioma: trans-sphenoidal surgery and intra-cystic apposition of "bleomycin wax".

    • Mario Francesco Fraioli, Laura Moschettoni, Elisabetta Catena, and Chiara Fraioli.
    • Department of Neurosciences, Neurosurgery, University of Rome Tor Vergata, Rome. Italy, b.fraioli@libero.it
    • Acta Neurochir (Wien). 2010 Feb 1;152(2):293-6.

    BackgroundThe current therapeutic approach to craniopharyngioma is multidisciplinary. Sub-total removal, followed by adjuvant treatments, especially in large cystic tumours, is an accepted regime reported by many authors.Case ReportA young patient with an intra- and suprasellar cystic craniopharyngioma was operated on via a microsurgical trans-sphenoidal approach, achieving sub-total removal and bleomycin mixed with bone wax ("bleomycin wax") applied to the capsular remnant.ResultsPre-operative neurological and endocrinological deficit improved after surgery. There was no evidence of tumour recurrence after a follow-up period of 5.4 years.ConclusionsThe intra-operative use of "bleomycin-wax" should be limited to those patients in whom intra-operative CSF fistula does not occur.

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