• Neuron · Feb 2003

    Review

    Synaptic ribbon. Conveyor belt or safety belt?

    • T D Parsons and P Sterling.
    • Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. thd@vet.upenn.edu
    • Neuron. 2003 Feb 6;37(3):379-82.

    AbstractThe synaptic ribbon in neurons that release transmitter via graded potentials has been considered as a conveyor belt that actively moves vesicles toward their release sites. But evidence has accumulated to the contrary, and it now seems plausible that the ribbon serves instead as a safety belt to tether vesicles stably in mutual contact and thus facilitate multivesicular release by compound exocytosis.

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