• Ned Tijdschr Geneeskd · Feb 1999

    Clinical Trial

    [Results of extracorporeal membrane oxygenation in 100 newborns with cardiorespiratory insufficiency].

    • A F van Heijst, F H van der Staak, W B Geven, H Wilbers, M van de Bor, and C Festen.
    • Afd. Kindergeneeskunde, Academisch Ziekenhuis, Nijmegen.
    • Ned Tijdschr Geneeskd. 1999 Feb 13;143(7):356-60.

    ObjectiveTo describe the results of treatment with extracorporeal membrane oxygenation (ECMO) in newborns with severe cardiorespiratory insufficiency.DesignProspective, descriptive.MethodsFor all 100 newborns treated with ECMO in 1989-1997 in the Academic Hospital Nijmegen, department of Neonatology, the Netherlands, indications for treatment, complications during treatment and mortality within 6 weeks after cessation of ECMO were registered.ResultsThe 100 children comprised 66 boys and 34 girls, with a mean age of 2 days (range: 1-15). Indications for ECMO treatment were: meconium aspiration syndrome: 39 with 37 survivors (95%), congenital diaphragmatic hernia: 31 with 23 survivors (74%), sepsis or pneumonia: 20 with 14 survivors (70%) and 'others' among which persistent pulmonary hypertension of the newborn: 10 with 8 survivors (80%). Eighteen children died (18%). Causes of death were rebound pulmonary hypertension (9 times), intracranial haemorrhage (4), multi-organ failure (3) and pulmonary problems (2). The most important complications during treatment were bleeding problems (29), clotting problems (20) and infections (11).

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