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- T Suzuki, J Kato, S Saeki, S Ogawa, and H Suzuki.
- Department of Anesthesiology, Surugadai Nihon University Hospital, Tokyo.
- Masui. 1996 May 1;45(5):629-33.
AbstractWe investigated the analgesic effect of dextromethorphan (DM), a non-selective NMDA receptor antagonist, in 25 patients with postherpetic neuralgia (PHN). We administered DM 45mg.day-1 orally for 14 days and then 90mg.day-1 for next 14 days. Decrease in pain intensity and alleviation of allodynia were observed in 9 patients (36%). Side effects with no severe cases occurred in 8 patients (32%) and these were mainly digestive symptoms. We concluded that DM might be useful to treat PHN with allodynia probably due to central sensitization.
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