• Anaesthesia · Jun 1984

    Randomized Controlled Trial Comparative Study Clinical Trial

    Plasma catecholamine concentrations. The effects of infiltration with local analgesics and vasoconstrictors during nasal operations.

    • S Taylor, K Achola, and G Smith.
    • Anaesthesia. 1984 Jun 1;39(6):520-3.

    AbstractPlasma catecholamine concentrations were measured in 19 patients allocated randomly to receive submucous infiltration with 4 ml of either 0.5% lignocaine with adrenaline 1:200 000 or prilocaine 0.5% with octapressin 0.03 iu per ml. Venous blood samples were obtained before and at 2, 5, and 10 minutes following infiltration. Plasma adrenaline increased from 0.35 to 1.72 p mol/ml at 2 minutes infiltration with the former solution whilst there was little change in plasma noradrenaline concentration. No similar peak in adrenaline concentration occurred after infiltration with prilocaine/ octapressin solutions but with both solutions there was a small increase in plasma noradrenaline and adrenaline concentrations 10 minutes after infiltration, at the time of surgical stimulation.

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