• Shannon M Smith, Dagmar Amtmann, Robert L Askew, Jennifer S Gewandter, Matthew Hunsinger, Mark P Jensen, Michael P McDermott, Kushang V Patel, Mark Williams, Elizabeth D Bacci, Laurie B Burke, Christine T Chambers, Stephen A Cooper, Penney Cowan, Paul Desjardins, Mila Etropolski, John T Farrar, Ian Gilron, I-zu Huang, Mitchell Katz, Robert D Kerns, Ernest A Kopecky, Bob A Rappaport, Malca Resnick, Vibeke Strand, Geertrui F Vanhove, Christin Veasley, Mark Versavel, Ajay D Wasan, Dennis C Turk, and Robert H Dworkin.
• aDepartment of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA bDepartment of Rehabilitation Medicine, University of Washington, Seattle, WA, USA cInstitute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA dSchool of Professional Psychology, Pacific University, Hillsboro, OR, USA eDepartment of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA fDepartment of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA gDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA hEvidera, Seattle, WA, USA iLORA Group, LLC, Royal Oak, MD, USA jUniversity of Maryland, Baltimore, MD, USA kDepartment of Pediatrics, Dalhousie University, Halifax, NS, Canada lDepartment of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada mCentre for Pediatric Pain Research, IWK Health Center, Halifax, NS, Canada nPalm Beach Gardens, FL, USA oAmerican Chronic Pain Association, Rocklin, CA, USA pDesjardins Associates, Maplewood, NJ, USA qJohnson & Johnson, Titusville, NJ, USA rDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA sDepartment of Anesthesia, University of Pennsylvania, Philadelphia, PA, USA tDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA uDepartment of Anesthesiology & Perioperative Medicine, Queen's University, Kingston, ON, Canada vDepartment of Biomedical & Molecular Sciences, Queen's University, Kingston, ON, Canada wJazz Pharmaceuticals, Palo Alto, CA, USA xPurdue Pharma L.P., Stamford, CT, USA yVA Connecticut Healthcare System, West Haven, CT, USA zDepartment of Psychiatry, Yale University, New Haven, CT, USA aaDepartment of Neurology, Yale University, New Haven, CT, USA bbDepartment of Psychology, Yale University, New Haven, CT, USA ccCollegium Pharmaceutical,
• Pain. 2016 May 1; 157 (5): 1056-64.

AbstractClinical trial participants often require additional instruction to prevent idiosyncratic interpretations regarding completion of patient-reported outcomes. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership developed a training system with specific, standardized guidance regarding daily average pain intensity ratings. A 3-week exploratory study among participants with low-back pain, osteoarthritis of the knee or hip, and painful diabetic peripheral neuropathy was conducted, randomly assigning participants to 1 of 3 groups: training with human pain assessment (T+); training with automated pain assessment (T); or no training with automated pain assessment (C). Although most measures of validity and reliability did not reveal significant differences between groups, some benefit was observed in discriminant validity, amount of missing data, and ranking order of least, worst, and average pain intensity ratings for participants in Group T+ compared with the other groups. Prediction of greater reliability in average pain intensity ratings in Group T+ compared with the other groups was not supported, which might indicate that training produces ratings that reflect the reality of temporal pain fluctuations. Results of this novel study suggest the need to test the training system in a prospective analgesic treatment trial.

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