• Sci China Life Sci · Dec 2010

    Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin.

    • Shaohui Chen, Jing Zhao, Yuguang Huang, Ailun Luo, Pingping Zuo, Nan Yang, and Wenyu Hao.
    • Department of Anesthesia, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
    • Sci China Life Sci. 2010 Dec 1;53(12):1428-32.

    AbstractThe aim of this study was to investigate the role of endogenous enkephalin in the cerebral antihyperalgesic action of gabapentin. Neuropathic pain models and antihyperalgesic effect of gabapentin were confirmed by the presentation and changes of mechanical allodynia and thermal hyperalgesia of operated mouse hind paws. The results suggested that endogenous enkephalin may not be involved in the antihyperalgesic effect of gabapentin.

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