• E H Philipson, B R Kuhnert, R Pimentel, and S B Amini.
• Department of Obstetrics and Gynecology, Case Western Reserve University School of Medicine, Cleveland Metropolitan General Hospital, Ohio 44109.
• Anesth. Analg. 1989 Nov 1;69(5):604-7.

AbstractTransient maternal hypotension following regional anesthesia can lead to significantly lower umbilical cord pH values. Although this acidosis has not been found to be clinically significant, acidosis may increase the placental transfer of local anesthetic agents as a result of "ion trapping." The purpose of this study was to examine the pharmacologic and clinical consequences of transient maternal hypotension following epidural anesthesia with 0.5% bupivacaine before cesarean section. Patients were divided into two groups based on the development of maternal hypotension, defined as a systolic blood pressure less than 100 torr or a decrease of 30% or more from the preanesthetic level. Thirteen patients (33%) developed hypotension that was corrected within 2.1 +/- 1.8 min. The pH of umbilical cord venous and arterial blood and the concentration of bupivacaine were significantly lower (P less than 0.05) in neonates of mothers in the hypotensive group than in neonates of mothers that did not develop hypotension. The results show, however, that transient maternal hypotension following epidural anesthesia does not lead to a greater placental transfer of bupivacaine due to "ion trapping" even though neonatal cord blood pH decreases.

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