• Y C Chu, S M Lin, Y C Huang, K W Hui, S K Tsai, and T Y Lee.
• Department of Anesthesiology, Veterans General Hospital-Taipei, Taiwan, R.O.C.
• Acta Anaesthesiol. Sin. 1997 Mar 1;35(1):15-20.

BackgroundMivacurium is considered a relaxant suitable for tracheal intubation in children due to its rapid onset. We compared the neuromuscular effects of mivacurium, with and without priming, in children undergoing elective surgery during halothane anesthesia.MethodsForty pediatric patients (2-10 yr, ASA class I) were randomly into 2 groups and studied under halothane anesthesia. The non-priming group (n = 20) received mivacurium 0.25 mg/kg, and the priming group (n = 20) received a priming dose of mivacurium 0.025 mg/kg, followed by an intubating dose of 0.225 mg/kg 3 min later. Thenar Electromyogram responsive to supramaximal train-of-four stimulation of the ulnar nerve at 12 s intervals was used as neuromuscular monitoring.ResultsThe onset time in the priming group was significantly faster than in the non-priming group (1.04 min vs. 1.7 min). The mean time from injection of intubating dose to spontaneous recovery to 25%, 50% and 75% twitch were not influenced by priming technique. Side effects, such as cutaneous flushing and hypotension, were unremarkable at this dose in children.ConclusionsPriming technique can significantly accelerates the onset of mivacurium in the pediatric patients under halothane anesthesia.

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