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- K Winkler, P Bieling, and S Bielack.
- Univ.-Krankenhaus-Kinderklinik, Abtlg. f. pädiatrische Hämatologie und Onkologie, Hamburg.
- Z Orthop Ihre Grenzgeb. 1992 Jul 1;130(4):285-9.
AbstractIntensified adjuvant chemotherapy increased the 4-year metastasis-free survival probability from 50% (COSS-77) to roughly 80% (COSS-86). Preoperative chemotherapy was found without recognizable hazard and promoting conservative surgery. Following resection the local failure rate ist significantly higher than after demolitive procedures, including rotation plasty (10.5% vs. 2.5%). Local failures bare a very poor prognosis (19/23 DOD). The acute therapy related mortality is less than 3%. Late toxicities like ototoxicity and cardiotoxicity are intriguing and deserve increased attention. The management of the osteosarcoma patient is a complex and difficult interdisciplinary task which is best performed in centers experienced in the treatment of malignant musculo-skeletal tumors.
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