• Nature medicine · Nov 2010

    Biomarkers in Alzheimer's disease drug development.

    • Kaj Blennow.
    • Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden. kaj.blennow@neuro.gu.se
    • Nat. Med. 2010 Nov 1;16(11):1218-22.

    AbstractBiomarkers may be of great value in Alzheimer's disease drug development to select the most optimal drug candidates for large and expensive phase 3 clinical trials. Biomarkers will also be important to provide evidence that a drug affects the underlying pathophysiology of the disease, which, together with a beneficial effect on the clinical course, will be essential for labeling the drug as having a disease-modifying effect.

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