• Reg Anesth Pain Med · Nov 2014

    Review

    Dose-Finding Methodology for Peripheral Nerve Blocks.

    • Theodosios Saranteas, Roderick J Finlayson, and De Q H Tran.
    • From the Department of Anesthesia, Montreal General Hospital, McGill University, Montreal, Quebec, Canada.
    • Reg Anesth Pain Med. 2014 Nov 1; 39 (6): 550-5.

    AbstractDose-finding studies enable the successful conduct of peripheral nerve blocks by ensuring the administration of appropriate doses of local anesthetic. However, the optimal dose-finding methodology remains ambiguous. In this research methodology article, we set out to review the basic aspects pertaining to dose-response curves (graded vs quantal), the pharmacodynamic indices required by dose-finding studies, the properties of different dose-finding methods (sigmoidal dose-response curve analysis, Dixon-Mood method, Biased Coin Design, and Bayesian analysis), as well as strategies and recommendations for future research.

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