• Acta Anaesthesiol Scand · Nov 2014

    Review

    Indocyanine green plasma disappearance rate as dynamic liver function test in critically ill patients.

    • B M Halle, T D Poulsen, and H P Pedersen.
    • Department of Anesthesia and Intensive Care, Copenhagen University Hospital Roskilde, Roskilde, Region Zealand, Denmark.
    • Acta Anaesthesiol Scand. 2014 Nov 1;58(10):1214-9.

    BackgroundIndocyanine green (ICG) is a water-soluble fluorescent dye that is bound to plasma protein when administered intravenously. Removal of ICG from the blood depends on hepatic blood flow, function of the parenchymal cells and biliary excretion. ICG elimination is described as a useful dynamic liver function test.MethodsIn this review, we looked at the most recent literature to clarify why ICG is useful in critically ill patients, the validity of the ICG plasma disappearance rate (ICG-PDR) measured transcutaneously and whether ICG-PDR has any prognostic value.ConclusionIn conclusion, measuring ICG-PDR is a valuable method for dynamic assessment of liver function, and is found to be a valuable prognostic tool in predicting survival for septic patients, patients presenting with acute liver failure and critically ill patients.© 2014 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

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