• Am J Emerg Med · Jun 2016

    Intravenous lipid emulsion prolongs survival in rats intoxicated with digoxin.

    • Bülent Serhan Yurtlu, Şule Özbilgin, Derya Arslan Yurtlu, Nilay Boztaş, Gonca Kamacı, Mahmut Akaltun, Volkan Hancı, and Osman Yılmaz.
    • Dokuz Eylül University, School of Medicine, Department of Anesthesiology and Reanimation. Electronic address: syurtlu68@gmail.com.
    • Am J Emerg Med. 2016 Jun 1; 34 (6): 1112-6.

    BackgroundIntravenous lipid emulsion eliminates the toxicity-related symptoms of several drugs. We hypothesized that intravenous lipid emulsion prolongs the survival time in digoxin-intoxicated rats.MethodsElectrocardiograms of 14 anesthesized Wistar rats were monitored. All of the rats received digoxin infusion at a rate of 12 mL/h (0.25 mg/mL). Five minutes after the start of digoxin infusion, animals were treated either with 12.4 mL/kg intravenous lipid emulsion (group L) or saline (group C). The primary outcome variable was time elapsed until asystole development. Cumulative dose of digoxin required to induce asystole was also recorded.ResultsMean time until asystole development in groups C and L were 21.28 ± 8.61 and 32.00 ± 5.41 minutes, respectively (P< .05). The mean lethal doses of digoxin in the groups C and L were 3.97 ± 1.54 and 6.09 ± 0.96 mg/kg, respectively (P< .05).ConclusionIntravenous lipid emulsion prolonged the time until asystole development and increased cumulative lethal dose in rats intoxicated with digoxin.Copyright © 2016 Elsevier Inc. All rights reserved.

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