• Vincenzo Fodale, Caterina Praticó, Marco Tescione, Tullio Lucanto, Salvatore Tanania, and Letterio B Santamaria.
• University of Messina, Department of Neuroscience Psychiatric and Anesthesiological Sciences, Policlinico Universitario G. Martino, Messina, Italy. vfodale@unime.it
• Surg Laparosc Endosc Percutan Tech. 2005 Jun 1;15(3):149-52.

AbstractTo compare the intraoperative costs of intravenous propofol-based anesthesia for laparoscopic cholecystectomy, a total of 42 patients were randomly assigned to receive remifentanil or fentanyl as adjuvant using the bispectral index anesthesia monitoring. The average anesthesia calculated costs per hour (and per minute) were 79.45 (1.32) in the fentanyl group and 65.36 (1.09) in the remifentanil group. The calculated mean cost per patient was 76.56 in the fentanyl group and 58.86 in the remifentanil group. In conclusion, for propofol-cisatracurium-based anesthesia for laparoscopic surgery, when applying the bispectral index to guide the administration of hypnotic anesthetic drugs and ensure an adequate and stable depth of anesthesia, the cost of anesthesia is lower using remifentanil as an adjuvant rather than fentanyl. The clinical relevance is that it could be the intravenous anesthesia technique of choice in laparoscopic surgery for cholecystectomy from a cost-minimization standpoint.

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