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- Eduardo Fernandes Bondan, Maria Anete Lallo, Heloísa Orsini, Henri Levi Donnaruma Bentubo, Angela Yazbek, Daclê Juliani Macrini, Maria Martha Bernardi, and Dominguita Luhers Graça.
- Universidade Paulista, Rua Caconde 125/51, 01425-011 São Paulo SP, Brazil. bondan@uol.com.br
- Arq Neuropsiquiatr. 2006 Jun 1;64(2B):496-503.
AbstractEthidium-bromide (EB)-induced lesions have been used to investigate the incomplete remyelination in the central nervous system, as well as to evaluate therapeutic strategies to accelerate the reconstruction of the lost myelin sheaths. Although many electrophysiologic studies were performed in situations of experimental demyelination and remyelination, their behavioural effects have not been properly analyzed. In this study, we investigated ultrastructurally the EB - demyelinating lesions as well as the locomotor activity of rats during the beam walking test after a focal induction of demyelination using the EB model in the ventral surface of the brainstem. It was observed the occurrence of locomotor deficits until 31 days post-injection, as well as that subsequent remyelination was related to the return of the lost function.
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