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Curr Opin Pharmacol · Feb 2012
ReviewHyperalgesia by synaptic long-term potentiation (LTP): an update.
- Jürgen Sandkühler and Doris Gruber-Schoffnegger.
- Medical University of Vienna, Center for Brain Research, Department of Neurophysiology, Spitalgasse 4, A-1090 Vienna, Austria. juergen.sandkuehler@meduniwien.ac.at
- Curr Opin Pharmacol. 2012 Feb 1;12(1):18-27.
AbstractLong-term potentiation of synaptic strength (LTP) in nociceptive pathways shares principle features with hyperalgesia including induction protocols, pharmacological profile, neuronal and glial cell types involved and means for prevention. LTP at synapses of nociceptive nerve fibres constitutes a contemporary cellular model for pain amplification following trauma, inflammation, nerve injury or withdrawal from opioids. It provides a novel target for pain therapy. This review summarizes recent progress which has been made in unravelling the properties and functions of LTP in the nociceptive system and in identifying means for its prevention and reversal.Copyright © 2011 Elsevier Ltd. All rights reserved.
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