• Dimitrios N Lyras, Konstantinos Kazakos, Marios Tryfonidis, George Agrogiannis, Sotirios Botaitis, Anna Kokka, George Drosos, Konstantinos Tilkeridis, and Dionysios Verettas.
• Democritus University of Thrace, Department of Orthopaedic and Trauma Surgery, Dragana, BO 84100, Greece.
• Foot Ankle Surg. 2010 Sep 1;16(3):137-41.

BackgroundTo investigate the effect of platelet-rich plasma (PRP) on TGF-beta1 expression during tendon healing.MethodsWe used 48 skeletally mature New Zealand White rabbits. 24 rabbits received the PRP, and 24 rabbits served as an untreated control group. Equal numbers of animals were sacrificed at 1st, 2nd, 3rd, and 4th week. The surgical procedure involved a transverse incision to transect the Achilles tendon. A volume of 1ml of PRP was then injected into the tendon mass in the PRP group. Histological and immunohistochemical evaluations with an anti-TGF-beta primary antibody were performed.ResultsThe pattern of expression of TGF-beta1 in the PRP group was characterized by a significant upregulation during the first 2 weeks and subsequently significant downregulation in the 3rd and 4th week in comparison with the controls.ConclusionsOur results suggest that PRP may affect the tendon healing process by altering the expression of TGF-beta1.Copyright (c) 2009 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.

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