• Parkinsonism Relat. Disord. · Apr 2006

    Clinical Trial

    Chronic stimulation of the subthalamic nucleus increases daily on-time without dyskinesia in advanced Parkinson's disease.

    • A T Portman, T van Laar, M J Staal, A W F Rutgers, H L Journee, and K L Leenders.
    • Department of Neurology, University Medical Center, Groningen, The Netherlands.
    • Parkinsonism Relat. Disord. 2006 Apr 1;12(3):143-8.

    AbstractWe assessed the efficacy of chronic stimulation of the subthalamic nucleus (STN-DBS) in 20 patients with Parkinson's disease (PD) by means of clinical assessments and patient diaries 12 months after surgery. STN-DBS reduced the UPDRS part III off-medication score by 33%, and successively improved complete daily on-time without dyskinesia at 12 months significantly. In conclusion, our study demonstrates the efficacy of chronic STN-DBS on motor features in a selected population of advanced PD patients. In addition to clinical assessments, patients' diaries serve as an essential tool to evaluate the functional motor status after STN-DBS.

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