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Case Reports
Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke.
- M D Hill, P A Barber, J Takahashi, A M Demchuk, T E Feasby, and A M Buchan.
- Department of Clinical Neurosciences, University of Calgary, Alta. michael.hill@crha-health.ab.ca
- CMAJ. 2000 May 2;162(9):1281-4.
AbstractAmong 105 patients given recombinant tissue plasminogen activator (rt-PA, alteplase) intravenously for acute stroke, 2 (1.9%) had lingual angioedema, which progressed to a fatal anaphylactoid reaction in 1. The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy.
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