• Anouk J M Rombouts, Cherry E Koh, Jane M Young, Lindy Masya, Rachael Roberts, Katie De-Loyde, Johannes H W de Wilt, and Michael J Solomon.
• 1 Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands 2 Surgical Outcomes Research Centre, Sydney Local Health District and Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia 3 Department of Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
• Dis. Colon Rectum. 2015 Jan 1;58(1):65-73.

BackgroundRadiotherapy reduces local recurrence rates but is also capable of short- and long-term toxicity. It may also render treatment of local recurrence more challenging if it develops despite previous radiotherapy.ObjectiveThis study examined the impact of radiotherapy for the primary rectal cancer on outcomes after pelvic exenteration for local recurrence.DesignWe conducted a retrospective review of exenteration databases.SettingThe study took place at a quaternary referral center that specializes in pelvic exenteration.PatientsPatients referred for pelvic exenteration from October 1994 to November 2012 were reviewed. Patients who did and did not receive radiotherapy as part of their primary rectal cancer treatment were compared.Main Outcome MeasuresThe main outcomes of interest were resection margins, overall survival, disease-free survival, and surgical morbidities.ResultsThere were 108 patients, of which 87 were eligible for analysis. Patients who received radiotherapy for their primary rectal cancer (n = 41) required more radical exenterations (68% vs 44%; p = 0.020), had lower rates of clear resection margins (63% vs 87%; p = 0.010), had increased rates of surgical complications per patient (p = 0.014), and had a lower disease-free survival (p = 0.022). Overall survival and disease-free survival in patients with clear margins were also lower in the primary irradiated patients (p = 0.049 and p < 0.0001). This difference in survival persisted in multivariate analysis that corrected for T and N stages of the primary tumor.LimitationsThis study is limited by its retrospective nature and heterogeneous radiotherapy regimes among radiotherapy patients.ConclusionsPatients who previously received radiotherapy for primary rectal cancer treatment have worse oncologic outcomes than those who had not received radiotherapy after pelvic exenteration for locally recurrent rectal cancer.

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