• Ned Tijdschr Geneeskd · Dec 2002

    Case Reports

    [Methemoglobinemia due to ingestion of isobutyl nitrite ('poppers')].

    • M T C Pruijm and P H E M de Meijer.
    • Leids Universitair Medisch Centrum, afd. Algemene Interne Geneeskunde, Postbus 9600, 2300 RC Leiden. m.pruijm@wanadoo.nl
    • Ned Tijdschr Geneeskd. 2002 Dec 7;146(49):2370-3.

    AbstractTwo male students, aged 20 and 21 years, developed central cyanosis shortly after drinking 5 ml of 'poppers' (isobutyl nitrite). They presented with methaemoglobinaemia and were hospitalised. After treatment with oxygen and intravenous fluids they could be discharged in good health the following day. Poppers are alkyl nitrites with vasdilative and oxidizing properties. They are used as party drugs (i.e. inhaled) because of their short-lived euphoric effect. Overdose can result in methaemoglobinaemia: the presence of oxidized haemoglobin which is unable to transport oxygen. Depending on the serum level of methaemoglobin this may result in central cyanosis, unconsciousness, coma and even death. Patients with high methaemoglobin levels should be treated with i.v. methylene blue.

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