• Pediatric emergency care · Nov 2007

    Case Reports

    Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy.

    • Michael Ganetsky, Kavita M Babu, and Edward W Boyer.
    • Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA. mganetsky@comcast.net
    • Pediatr Emerg Care. 2007 Nov 1;23(11):829-31.

    AbstractAn 18-year-old male developed a severe serotonin syndrome after recreational ingestion of Coricidin HBP (chlorpheniramine 4 mg and dextromethorphan hydrobromide 30 mg). Propofol infusion rapidly normalized his agitation, neuromuscular hyperactivity, and autonomic instability. Confirmatory analysis demonstrated a dextromethorphan serum concentration of 930 ng/mL. Dextromethorphan can produce serotonin syndrome in the absence of another serotonergic drug.

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