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Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi · Feb 2013
Review[Regeneration strategies of intervertebral disc].
- Weili Fu and Zhou Xiang.
- Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
- Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2013 Feb 1;27(2):227-32.
ObjectiveTo review the research progress of the seed cells, scaffolds, growth factors, and the prospects for clinical application of the intervertebral disc regeneration.MethodsThe recent literature concerning the regeneration strategies and tissue engineering for treatment of degenerative intervertebral disc disease was extensively reviewed and summarized.ResultsSeed cells based on mesenchymal stem cells (MSCs) and multiple-designed biomimetic scaffolds are the hot topic in the field of intervertebral disc regeneration. It needs to be further investigated how to effectively combine the interactions of seed cells, scaffolds, and growth factors and to play their regulation function.ConclusionThe biological regeneration of intervertebral disc would have a very broad prospects for clinical application in future.
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