• Biological psychiatry · Nov 1993

    Pain perception threshold in major depression.

    • G Adler and W F Gattaz.
    • Unit Neurobiology of Functional Psychoses, Central Institute of Mental Health, Mannheim, Germany.
    • Biol. Psychiatry. 1993 Nov 15;34(10):687-9.

    AbstractSomatosensory perception threshold (SPT) and pain perception threshold (PPT) were studied in 16 patients with major depression, compared to the findings in an age-matched and gender-matched control group and related to the psychopathological state evaluated by means of the Hamilton Depression Scale. Perception thresholds were assessed by means of a noninvasive high-frequency electric skin stimulation. Absolute perception thresholds were increased in the patients. However, the relative pain perception threshold (RPPT = PPT: SPT) was significantly reduced. RPPT was positively correlated with retardation. It was negatively correlated with anxiety, suggesting that a reduction of pain perception thresholds in depressive patients may be attributed to anxiety and impaired stress-coping.

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