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Indian J Crit Care Med · Jan 2011
Drug interaction leading to prolonged sedation in a postoperative high risk coronary bypass surgery patient.
- Shrikant Bobade, Vinay Kulkarni, Sudhir Dhumne, Saurabh Barde, Jitesh Chauhan, and Avinash Sharma.
- Department of Anaesthesiology and Critical Care, CARE Hospital, Nagpur, India.
- Indian J Crit Care Med. 2011 Jan 1;15(1):55-7.
AbstractUse of midazolam infusion in mechanically ventilated patient is an established practice in critical care. In our case, the use of erythromycin as a prokinetic agent for better tolerance of enteral feeding and paralytic ileus led to an interaction between midazolam and erythromycin, which resulted in prolonged and deeply sedated patient. In a critically ill patient, there is always a possibility of multiple drug interactions. It is important to understand them and they should be considered before starting new medication.
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