• Clin. Infect. Dis. · Dec 2007

    Case Reports

    Treatment of refractory Babesia microti infection with atovaquone-proguanil in an HIV-infected patient: case report.

    • Jatin M Vyas, Sam R Telford, and Gregory K Robbins.
    • Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. jvyas@partners.org
    • Clin. Infect. Dis. 2007 Dec 15;45(12):1588-90.

    AbstractA patient with acquired immune deficiency syndrome presented with babesiosis 6 months after presumed tick exposure. Despite initial treatment with azithromycin and atovaquone, followed by quinine and clindamycin, he experienced an increasing parasite load. Finally, red blood cell exchange transfusion, anti-Babesia therapy, and the addition of atovaquone-proguanil to the treatment regimen led to symptomatic improvement and elimination of parasitemia. Low-level parasitemia recurred 20 weeks later and was eradicated by administration of atovaquone-proguanil monotherapy. Atovaquone-proguanil appears to have activity against babesiosis and should be studied as a potential therapy for patients with refractory babesiosis.

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