• La Tunisie médicale · Oct 2011

    Review

    [N-acetylcysteine in septic shock].

    • Omar Ellouze, Nabil Frikha, Sonia Ouerghi, Taher Mestiri, and Mohamed Salah Ben Ammar.
    • Universite Tunis, El Manar, Tunisie.
    • Tunis Med. 2011 Oct 1;89(10):738-44.

    AimTo focus on the various studies evaluating the effects of Nacetylcysteine in septic shockMethodsMain references obtained from the medical database Medline using the keywords: N-acetylcysteine; septic shock, free radicals.ResultsSeptic shock remains the leading cause of mortality in intensive care units. The progressive knowledge of the pathophysiology of septic shock, underline the production of free radicals and their cellular and microcirculatory effects. The Nacetylcysteine used mainly in paracetamol poisoning, has properties to control free radicals. The explosion of free radicals in septic shock has led to multiple studies assessing the role of N-acetylcysteine as an anti radical, and for its anti inflammatory action.ConclusionNAC seems to play an important role in septic shock to control free radicals and the inflammatory response. But these results remain contradictory. Some larger and more standardized studies should allow to evaluate the actual effects of NAC in septic shock.

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