• Der Anaesthesist · Feb 2000

    Randomized Controlled Trial Clinical Trial

    [The effect of different priming doses on the pharmacodynamics of cisatracurium].

    • F K Pühringer, A Scheller, A Kleinsasser, A Löckinger, P Keller, C Raedler, and C Keller.
    • Universitätsklinik für Anaesthesie und Allgemeine Intensivmedizin, Leopold Franzens Universität Innsbruck, Osterreich. friedrich.puehringer@uibk.ac.at
    • Anaesthesist. 2000 Feb 1;49(2):102-5.

    ObjectiveThe aim of the study was to evaluate the effect of two different priming regimen on the onset time of 100 micrograms/kg cisatracurium, when compared to bolus administration.Methods51 patients were randomly assigned and received either a bolus of 100 micrograms/kg cisatracurium, or a priming dose of 10 micrograms/kg cisatracurium followed after 4 min by 90 micrograms/kg cisatracurium, or a priming dose of 15 micrograms/kg cisatracurium followed after 4 min by 85 micrograms/kg cisatracurium. The neuromuscular monitoring was performed using a mechanomyograph (Groningen II Monitor). Anaesthesia was induced with propofol and fentanyl and maintained by continuous infusion of propofol.ResultsThe priming combination of 15 micrograms/kg cisatracurium followed after 4 min by 85 micrograms/kg cisatracurium produced a statistically significant reduction in the onset time (95% block) (180 +/- 60 s) and time to complete block (210 +/- 48 s), when compared to the bolus group (240 +/- 60 s and 288 +/- 66 s) (p < 0.05).ConclusionOur data indicate that the "priming principle" is an appropriate technique to shorten the onset time of cisatracurium. To achieve a maximum effect the priming combination of 15 micrograms/kg cisatracurium followed after 4 min by 85 micrograms/kg cisatracurium is recommended.

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