• World J Surg Oncol · Jan 2013

    Case Reports

    Complete resection of recurrent and initially unresectable dermatofibrosarcoma protuberans downsized by Imatinib.

    • Dennis A Wicherts, Frits van Coevorden, Houke M Klomp, Martine A van Huizum, J Martijn Kerst, Rick L M Haas, Hester H van Boven, and J A van der Hage.
    • Department of Surgical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands.
    • World J Surg Oncol. 2013 Jan 1;11:59.

    AbstractCurative surgical treatment of recurrent, locally advanced dermatofibrosarcoma protuberans is often limited owing to a close relation of the tumor with important anatomical structures. Targeted therapy with imatinib, a tyrosine kinase inhibitor, may cause significant reduction of tumor volume, thereby enabling radical surgery. This treatment strategy, therefore, offers a chance of cure for selected patients with advanced dermatofibrosarcoma protuberans. In addition, preoperative treatment with imatinib may decrease possible disfigurement related to radical surgery for large tumors.

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