• Daniel Alcolea, Pablo Martínez-Lage, Andrea Izagirre, Montserrat Clerigué, María Carmona-Iragui, Rosa María Alvarez, Juan Fortea, Mircea Balasa, Estrella Morenas-Rodríguez, Albert Lladó, Oriol Grau, Kaj Blennow, Alberto Lleó, and José L Molinuevo.
• Department of Neurology, Inst. Investigacions Biomèdiques-Hospital Sant Pau, Universitat Autónoma de Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, CIBERNED, Spain.
• J. Alzheimers Dis. 2014 Jan 1;39(4):719-26.

BackgroundLumbar puncture (LP) is increasingly performed in memory units due to the usefulness of cerebrospinal fluid (CSF) biomarkers in the diagnosis of Alzheimer's disease. The feasibility of this procedure in this context, however, is controversial.ObjectiveOur aim was to analyze the incidence of complications and their associated factors so as to determine the impact of LP in the study of CSF biomarkers of Alzheimer's disease.MethodsIn the context of a larger international initiative, we prospectively collected data from 689 participants who underwent LP in three memory units in Spain. Data included demographic factors, headache history, subjective attitude toward the procedure, patient positioning, needle characteristics, volume of CSF extracted, attempts needed, and resting time after CSF acquisition. Five to seven days after the procedure, we asked participants about complications through a semi-structured telephone interview.ResultsNo adverse events were reported in 441 (64.0%) participants. The most frequent complication was headache, reported by 171 (24.8%) subjects. It was severe in only 17 (2.5%). Headache was more frequent in younger participants and when a cutting-edge needle was used. Back pain was present in 111 (16.1%) cases, and it was associated with female gender, cutting-edge needles, increased number of attempts, and longer resting time after LP. No major complications were reported. The use of pen-point needles showed a trend toward a higher frequency of hematic CSF.ConclusionLP can be safely performed to study CSF biomarkers. The main complication is headache, associated with younger age and use of cutting-edge needles.

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