• Brain Stimul · Mar 2014

    Temporal rearrangement of pre-ictal PTZ induced spike discharges by low frequency electrical stimulation to the amygdaloid complex.

    • Daniel Castro Medeiros, Luciano Borges Oliveira, Flávio Afonso Gonçalves Mourão, Cristiane Perácio Bastos, Norberto Garcia Cairasco, Grace Schenatto Pereira, Eduardo Mazoni Andrade Marçal Mendes, and Márcio Flávio Dutra Moraes.
    • Núcleo de Neurociências (NNC), Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas - Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais CEP 31270-901, Brasil; Centro de Tecnologia e Pesquisa em Magneto-Ressonância, Escola de Engenharia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais CEP 31270-901, Brasil.
    • Brain Stimul. 2014 Mar 1;7(2):170-8.

    BackgroundEpilepsy is a common neurological disease affecting over 40 million people worldwide. The foremost important challenge of epileptologists has been to control and predict the recurrent and spontaneous seizures of epileptic patients. The application of low frequency electrical stimulation (LFS) in deep brain structures has shown promising results in seizure control. However, the use of LFS as a probing strategy for seizure prediction, thus contributing to a closed loop solution, is still poorly explored.ObjectiveTo improve seizure prediction by producing gradually increasing phase-locked pre-ictal electrographical responses, due to the short-term plastic changes in epileptogenic neural networks, thus behaving as a "programmed" surrogate marker.MethodsUrethane anesthetized rats were divided into 3 groups: the PTZ-noES group was injected with pentylenetetrazole (PTZ 4 mg/ml/min flow rate) i.v. without electrical stimulation (ES); the ES-noPTZ group received ES (0.5 Hz, 0.1 ms pulse width and 0.6 mA) to the amygdaloid complex and the PTZ + ES group received simultaneously i.v. PTZ infusion and ES. After each condition, electrographical parameters and c-Fos expression of regions of interest were evaluated.ResultsAlthough the PTZ + ES group had no evident change in the sustained electrographic seizure onset, duration and/or frequency spectrum; c-Fos labeling showed a different expression pattern when compared to the PTZ-noES and ES-noPTZ. Also, PTZ + ES formed a gradually increasing evoked potential; confirming the strong coupling of reverberant neural networks induced by ES - phase locked to stimuli.ConclusionES induces a detectable temporal rearrangement of pre-ictal activity, which has suggestive applicability to seizure prediction.Copyright © 2014 Elsevier Inc. All rights reserved.

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