• Anaesthesia · Apr 1997

    Randomized Controlled Trial Clinical Trial

    The effect of clonidine on sevoflurane requirements for anaesthesia and hypnosis.

    • T Katoh and K Ikeda.
    • Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan.
    • Anaesthesia. 1997 Apr 1;52(4):377-81.

    AbstractWe evaluated the effects of clonidine given orally on sevoflurane requirements for anaesthesia and hypnosis. Patients received either clonidine (5 micrograms.kg-1) by mouth (n = 21) 90 min before surgery or no premedication (n = 21) by random allocation. MAC was calculated using repeated tetanic nerve stimulation with end-tidal sevoflurane concentration increased or decreased by 0.3 vol.% depending on the previous response. MAC awake was calculated according to the response to verbal command. The mean (SD) MAC in the clonidine-treated patients was 1.53 (0.20)% compared with 1.83 (0.15)% in the control group (p < 0.001). Similarly, MAC awake was reduced in the clonidine group (0.50 (0.08)% compared with 0.60 (0.07)% in the control group) (p < 0.001). We conclude that clonidine 5 micrograms.kg-1 orally administered pre-operatively reduces sevoflurane requirements for anaesthesia and hypnosis.

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